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LOSE
Lose (verb) — fail to keep or to maintain; cease to have, either physically or in an abstract sense. 2. (verb) fail to win.
“She lost her purse when she left it unattended on her seat”
Lose is a valid 4-letter word worth 4 points in Scrabble (and Words With Friends letter values vary). Below are its anagrams and the shorter words hidden inside it.